The Seattle area was one of the hardest hit regions of the country early in the pandemic. Through our collaboration between Harvard University and the University of Washington, our group has been studying the impact of the pandemic on youth and maternal mental health through several longitudinal studies. Our focus is understanding how pandemic-related stressors impact the development of mental health problems, factors that increase this risk, as well as factors that promote resilience in the face of these stressors, including behavioral, social, economic and neural factors.